Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27340512 | 1.00 | TAAR1 (0.47) | TAAR1DRD2DRD3NAAAHIF1A | |
| SCHEMBL15445640 | 0.98 | TAAR1 (0.48) | TAAR1DRD2DRD3NAAAHIF1A | |
| SCHEMBL19824772 | 0.92 | TAAR1 (0.50) | TAAR1DRD2DRD3NAAAMEN1 | |
| SCHEMBL4503328 | 0.84 | — | — | |
| SCHEMBL9855401 | 0.82 | TAAR1 (0.65) | TAAR1DRD2DRD3NAAAMEN1 | |
| SCHEMBL10521145 | 0.80 | TAAR1 (0.62) | TAAR1DRD2DRD3NAAAMEN1 | |
| SCHEMBL7293979 | 0.78 | TAAR1 (0.47) | TAAR1DRD2DRD3NAAAMEN1 | |
| SCHEMBL9552934 | 0.73 | MEN1 (0.43) | HIF1AEPAS1MEN1KMT2ASLC6A2 | |
| SCHEMBL23897421 | 0.72 | TAAR1 (0.72) | TAAR1DRD2DRD3NAAA | |
| SCHEMBL1309811 | 0.72 | TAAR1 (0.54) | TAAR1DRD2DRD3NAAAGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1295072-A | New polycyclic system compound as neurotransmitter release reinforcer in treatment of identification fault and derivatives thereof | DU PONT PHARM CO (US) | 2001-05-16 | — | — | CN | claimed |
| CN-1295072-A | New polycyclic system compound as neurotransmitter release reinforcer in treatment of identification fault and derivatives thereof | DU PONT PHARM CO (US) | 2001-05-16 | — | — | CN | disclosed |