Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27456011 | 0.84 | CA12 (0.50) | ARCA12CA9KIF11HRH4 | |
| SCHEMBL3777284 | 0.81 | AR (0.55) | ARCA12CA9KIF11HRH4 | |
| SCHEMBL2216550 | 0.73 | S1PR1 (0.46) | HRH4PTGDR2PDE5APPARGPPARA | |
| Trifluoromethylbenzene SCHEMBL29009779 | 0.71 | TSHR (0.50) | PTGDR2ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL30946289 | 0.70 | KIF11 (0.63) | ARCA12CA9KIF11KDM4E | |
| SCHEMBL20660889 | 0.70 | KIF11 (0.63) | ARCA12CA9KIF11KDM4E | |
| SCHEMBL5630679 | 0.70 | PDE3B (0.60) | PDE5AALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL4294313 | 0.70 | AR (0.50) | ARCA12CA9KIF11KDM4E | |
| Valeric Acid SCHEMBL29009828 | 0.70 | HDAC3 (0.48) | PTGDR2ALDH1A1RXFP1 | |
| SCHEMBL762006 | 0.69 | CA12 (0.59) | ARCA12CA9KIF11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1129582-C | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2003-12-03 | — | — | CN | disclosed |
| CN-1329599-A | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2002-01-02 | — | — | CN | disclosed |