SCHEMBL27547154

SCHEMBL27547154

CCCC(=N)CCc1c[nH]c2ccc(NS(=O)(=O)c3cccc4ccccc34)cc12

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 18/20 0.72
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27573228 0.86 HTR6 (0.72) HTR6
SCHEMBL3143201 0.85 HTR6 (0.89) HTR6
SCHEMBL13333251 0.84 HTR6 (0.74) HTR6
SCHEMBL13333253 0.84 HTR6 (0.76) HTR6ALDH1A1HTT
SCHEMBL13333255 0.84 HTR6 (0.76) HTR6
SCHEMBL3143198 0.83 HTR6 (1.00) HTR6
SCHEMBL3147543 0.83 HTR6 (1.00) HTR6
SCHEMBL30464859 0.83 HTR6 (1.00) HTR6
SCHEMBL3153021 0.83 HTR6 (1.00) HTR6
Hydrochloric Acid SCHEMBL3142854 0.83 HTR6 (0.98) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1271052-C Sulfonamide derivatives, their preparation and use as medicaments ESTEVE LABOR DR (ES) 2006-08-23 CN claimed
CN-1599718-A Sulphonamide derivatives, the preparation thereof and the application of same as medicaments ESTEVE LABOR DR (ES) 2005-03-23 CN claimed
CN-1271052-C Sulfonamide derivatives, their preparation and use as medicaments ESTEVE LABOR DR (ES) 2006-08-23 CN disclosed
CN-1599718-A Sulphonamide derivatives, the preparation thereof and the application of same as medicaments ESTEVE LABOR DR (ES) 2005-03-23 CN disclosed