Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.96 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.96 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.96 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.96 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.96 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL18625071 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL2997 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL7987114 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL13696339 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL8049464 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL24599520 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL13154676 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL10820235 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL5183254 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL13076870 | 0.98 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114349699-B | Synthesis method of (R) -2- (4-methoxybenzyl) -4-methylene-1-p-toluenesulfonyl pyrrolidine | 叶艳影 | 2024-05-03 | — | — | CN | disclosed |
| CN-103717594-B | TRPV1 antagonists comprising dihydroxy substituents and uses thereof | 普渡制药公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-105693712-A | TRPV1 antagonists including dihydroxy substituent and uses thereof | 普渡制药公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-101835784-A | Spiral shell [piperidines-4,4'-thieno-[3,2-C] pyrans] derivative and related compound thereof as the inhibitor of the sigma receptor that is used for the treatment of mental illness | ESTEVE LABOR DR | 2010-09-15 | — | — | CN | disclosed |
| CN-101553486-A | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS (DK) | 2009-10-07 | — | — | CN | disclosed |
| CN-1364806-A | New polypeptide-human sigma receptor 11.55 and polynucleotide for encoding such polypeptide | BIOWINDOW GENE DEV INC (CN) | 2002-08-21 | — | — | CN | disclosed |
| CN-1331120-A | Polypeptide-human sigma jreceptor 15.07 and polynucleotide for coding it | BODE GENE DEV CO LTD SHANGHAI (CN) | 2002-01-16 | — | — | CN | disclosed |
| CN-1326948-A | New polypeptide-human sigma receptor 10.67 and polynucleotide for encoding such polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2001-12-19 | — | — | CN | disclosed |