Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 14/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 14/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27548017 | 0.99 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27483468 | 0.83 | KCNH2 (0.35) | AKR1C3AKR1C2SLC6A2SLC6A4HSD17B1 | |
| SCHEMBL27482390 | 0.81 | PTGS1 (0.35) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27466230 | 0.81 | APP (0.42) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2646133 | 0.81 | AKR1C3 (0.44) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27548020 | 0.80 | KCNH2 (0.58) | — | |
| SCHEMBL2647603 | 0.79 | APP (0.44) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27482764 | 0.78 | CYP1A2 (0.34) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2648910 | 0.78 | KCNH2 (0.47) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2646820 | 0.77 | AKR1C3 (0.41) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |