Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482390 | 0.85 | PTGS1 (0.35) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1859326 | 0.83 | APP (0.47) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1859328 | 0.83 | APP (0.47) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27465639 | 0.82 | KCNH2 (0.42) | GCKKCNH2METAP2METAP1SLC6A3 | |
| SCHEMBL27465641 | 0.82 | KCNH2 (0.42) | GCKKCNH2METAP2METAP1SLC6A3 | |
| SCHEMBL27548017 | 0.82 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2645824 | 0.82 | SLC6A3 (0.48) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27548024 | 0.81 | APP (0.40) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27482764 | 0.81 | CYP1A2 (0.34) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27482751 | 0.81 | KCNH2 (0.41) | GCKKCNH2METAP2METAP1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |