Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chloropyridine SCHEMBL27296934 | 0.83 | TDP1 (0.64) | TDP1NFE2L2NPC1RAB9AMEN1 | |
| Dipyridyl SCHEMBL27745333 | 0.81 | KDM4E (0.54) | TDP1MAPK1NPC1RAB9AATM | |
| 2-Chloropyridine SCHEMBL9366854 | 0.80 | — | — | |
| Tert-Butyl Formate SCHEMBL27787932 | 0.79 | TDP1 (0.52) | TDP1NFE2L2MEN1KMT2AALDH1A1 | |
| 2-Chloropyridine SCHEMBL28283236 | 0.79 | TDP1 (0.64) | TDP1NFE2L2NPC1RAB9AMEN1 | |
| Tert-Butyl Formate SCHEMBL27580501 | 0.79 | TDP1 (0.46) | TDP1NFE2L2MAPK1NPC1RAB9A | |
| 2-Chloropyridine SCHEMBL27506304 | 0.78 | TDP1 (0.76) | TDP1NFE2L2NPC1RAB9AMEN1 | |
| Tert-Butyl Formate SCHEMBL28100934 | 0.77 | TDP1 (0.54) | TDP1NFE2L2NPC1RAB9ASMN1; SMN2 | |
| 2-Chloropyridine SCHEMBL27596465 | 0.77 | TDP1 (0.73) | TDP1NFE2L2NPC1RAB9AMEN1 | |
| 2-Chloropyridine SCHEMBL28292211 | 0.77 | TDP1 (0.73) | TDP1NFE2L2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267948-A | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and methods of making the modulators | 弗特克斯药品有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-109476658-A | Substituted 5,6,7,8- tetrahydro [1,2,4] triazol [4,3-A] pyridine -3 (2H) -one and 2,5,6,7- tetrahydro -3H- pyrrolo- [2,1-c] [1,2,4] triazole -3- ketone and application thereof | 拜耳公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-102333776-A | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof | SANOFI AVENTIS | 2012-01-25 | — | — | CN | disclosed |
| CN-100352804-C | Amide derivatives | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |
| CN-1344249-A | Amide derivatives | ASTRAZENECA AB (SE) | 2002-04-10 | — | — | CN | disclosed |