Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2755230 | 0.88 | BRD4 (0.41) | CYP11B2CYP11B1MAPK14MAPK13RAF1 | |
| Hydrochloric Acid SCHEMBL236905 | 0.86 | BRD4 (0.40) | CYP11B2CYP11B1MAPK14MAPK13RAF1 | |
| SCHEMBL24317084 | 0.73 | KDM4E (0.42) | NPC1RAB9ACYP1A2CYP3A4ADORA3 | |
| SCHEMBL21757505 | 0.69 | OPRL1 (0.48) | NPY5RCYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21757521 | 0.69 | OPRL1 (0.48) | NPY5RCYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21757517 | 0.67 | OPRL1 (0.49) | CYP11B2OPRL1 | |
| SCHEMBL7259043 | 0.67 | CYP1A2 (0.48) | CYP11B2CYP11B1CYP17A1CYP1A2CYP2E1 | |
| SCHEMBL6645525 | 0.67 | C1S (0.43) | CYP11B2NPC1RAB9ACYP11B1CYP17A1 | |
| SCHEMBL18845580 | 0.66 | ADORA1 (0.46) | NPY5RNPC1RAB9ARAF1ADORA3 | |
| SCHEMBL17918659 | 0.66 | KDM4E (0.44) | NPC1RAB9AMAPK14MAPK13RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | NPY5R 4652/4885CYP11B2 3571/4885NPC1 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.