Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667031 | 0.92 | HCRTR2 (0.41) | HCRTR2EPHX1TDP1DRD2MEN1 | |
| SCHEMBL3813627 | 0.88 | HCRTR2 (0.32) | HCRTR2EPHX1 | |
| SCHEMBL3813302 | 0.85 | HCRTR2 (0.30) | HCRTR2 | |
| SCHEMBL28815172 | 0.84 | HCRTR2 (0.39) | HCRTR2EPHX1TDP1DRD2MEN1 | |
| SCHEMBL4757164 | 0.84 | HCRTR2 (0.30) | HCRTR2 | |
| SCHEMBL3810910 | 0.84 | HCRTR2 (0.30) | HCRTR2 | |
| SCHEMBL90580 | 0.82 | HCRTR2 (0.41) | HCRTR2EPHX1TDP1DRD2MEN1 | |
| SCHEMBL3809387 | 0.82 | LMNA (0.34) | LMNA | |
| SCHEMBL6863397 | 0.81 | HCRTR2 (0.40) | HCRTR2EPHX1TDP1DRD2MEN1 | |
| SCHEMBL27485317 | 0.80 | TSHR (0.39) | P2RX7ALDH1A1TSHRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1344245-A | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | WARNER LAMBER CO (US) | 2002-04-10 | — | — | CN | claimed |
| CN-104755482-B | functionalized 9-bromo-camptothecin derivatives | 内尔维阿诺医学科学有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-1170811-C | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | ��ʲ | 2004-10-13 | — | — | CN | disclosed |
| CN-1344245-A | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | WARNER LAMBER CO (US) | 2002-04-10 | — | — | CN | disclosed |