Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539703 | 1.00 | MAOB (0.55) | MAOBMAOABCHEMAPTOPRM1 | |
| SCHEMBL3158647 | 0.90 | MAOB (0.63) | MAOBMAOAMAPTOPRM1AOC3 | |
| SCHEMBL19245649 | 0.90 | MAOB (0.63) | MAOBMAOABCHEMAPTOPRM1 | |
| SCHEMBL12126536 | 0.89 | BCHE (0.62) | MAOBBCHEOPRM1CHRM2HTR1A | |
| SCHEMBL3158397 | 0.88 | MAPT (0.56) | MAOBMAOABCHEMAPTAOC3 | |
| SCHEMBL12128162 | 0.85 | BCHE (0.55) | MAOBBCHEOPRM1CHRM2HTR1A | |
| SCHEMBL9630022 | 0.84 | GFER (0.54) | MAOBMAOAMAPTOPRM1CHRM2 | |
| SCHEMBL3161700 | 0.84 | GFER (0.54) | MAOBMAOAMAPTOPRM1CHRM2 | |
| SCHEMBL12128173 | 0.83 | L3MBTL1 (0.56) | BCHEOPRM1CHRM2HTR1AADRA2A | |
| SCHEMBL12128225 | 0.83 | L3MBTL1 (0.56) | BCHEOPRM1CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1303374-A | Substituted indolinones, process for their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-07-11 | — | — | CN | disclosed |