Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 17/20 | 0.58 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.51 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174847 | 0.89 | ADORA3 (0.67) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL18496411 | 0.88 | ADORA3 (0.66) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL12764541 | 0.88 | ADORA3 (0.61) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL1930775 | 0.88 | ADORA3 (0.66) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL18496415 | 0.87 | PDE5A (0.59) | ADORA3KCNH2PDE5A | |
| SCHEMBL29154434 | 0.87 | ADORA3 (0.68) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL175433 | 0.87 | ADORA3 (0.68) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL19126593 | 0.86 | ADORA3 (0.59) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL256537 | 0.86 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL175568 | 0.86 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104892459-A | Riociguat intermediate and preparation method thereof | SUZHOU MIRACPHARMA TECHNOLOGY CO LTD | 2015-09-09 | — | — | CN | disclosed |
| CN-1330649-C | Carbamate-substituted pyrazolopyridines | BAYER AG (DE) | 2007-08-08 | — | — | CN | disclosed |
| CN-1665811-A | Carbamate-substituted pyrazolopyridines | BAYER AG (DE) | 2005-09-07 | — | — | CN | disclosed |