Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MYC | P01106 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636443 | 0.91 | MYC (0.50) | RXFP1MYCTTREPRS1CSNK2A1 | |
| SCHEMBL27482009 | 0.83 | DHODH (0.52) | MYCTTRCSNK2A1MCL1KDM4E | |
| SCHEMBL27458636 | 0.82 | TTR (0.59) | TTRCSNK2A1MCL1KDM4EHTT | |
| SCHEMBL27517441 | 0.81 | NPC1 (0.54) | MYCTTRCSNK2A1NR4A1MCL1 | |
| SCHEMBL27995052 | 0.81 | TTR (0.46) | MYCTTRCSNK2A1MCL1KDM4E | |
| SCHEMBL27498799 | 0.81 | DHODH (0.56) | TTRCSNK2A1MCL1KDM4ERXRA | |
| SCHEMBL27821953 | 0.81 | KDM4E (0.52) | RXFP1TTRCSNK2A1MCL1KDM4E | |
| SCHEMBL28028683 | 0.81 | TTR (0.46) | RXFP1MYCTTRCSNK2A1NR4A1 | |
| SCHEMBL27730165 | 0.80 | RXFP1 (0.45) | RXFP1MYCTTREPRS1NR4A1 | |
| SCHEMBL27999421 | 0.79 | HSD17B10 (0.51) | RXFP1EPRS1CSNK2A1MCL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849053-A | Spiro compounds | 卡利拉制药公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-1882553-A | Phenylacetic acid derivative, process for producing the same, and use | ONO PHARMACEUTICAL CO (JP) | 2006-12-20 | — | — | CN | disclosed |
| CN-1175256-A | tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |