Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isobutane SCHEMBL27558036 | 0.84 | SYK (0.39) | PHGDHMAPTPTGS2BRD4 | |
| Isobutane SCHEMBL27643374 | 0.83 | PHGDH (0.32) | PHGDHMAPTPTGS2BRD4 | |
| SCHEMBL1925748 | 0.81 | NR1H2 (0.39) | PTGS2 | |
| Isobutane SCHEMBL27575778 | 0.73 | KDM5B (0.37) | PTGS2 | |
| SCHEMBL27624100 | 0.72 | HTT (0.35) | PHGDHMAPTBRD4 | |
| SCHEMBL31467599 | 0.68 | MAPT (0.48) | PHGDHMAPTPTGS2 | |
| SCHEMBL4547930 | 0.67 | PHGDH (0.49) | PHGDHMAPT | |
| SCHEMBL1459530 | 0.66 | SMN1; SMN2 (0.45) | MAPTPTGS2 | |
| SCHEMBL11142730 | 0.65 | KMT2A (0.53) | BRD4 | |
| SCHEMBL27535251 | 0.64 | KMT2A (0.41) | MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1304379-C | Water-soluble phenylpyridazine compounds and compositions containing the same | KOWA CO (JP) | 2007-03-14 | — | — | CN | disclosed |
| CN-1759103-A | Water-soluble phenylpyridazine derivative and medicine containing the same | KOWA CO (JP) | 2006-04-12 | — | — | CN | disclosed |
| CN-1558903-A | Water-soluble phenylpyridazine derivative and drug containing the same | ������������ʽ���� | 2004-12-29 | — | — | CN | disclosed |