Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | GCK | P35557 | 10/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557977 | 0.93 | KCNH2 (0.47) | KCNH2GCKOPRM1OPRK1SLC6A2 | |
| SCHEMBL2642192 | 0.90 | GCK (0.50) | KCNH2GCKOPRM1OPRK1NOTUM | |
| SCHEMBL2653752 | 0.90 | GCK (0.50) | KCNH2GCKOPRM1OPRK1NOTUM | |
| SCHEMBL27557961 | 0.88 | KCNH2 (0.45) | KCNH2GCKOPRM1OPRK1NOTUM | |
| SCHEMBL27616313 | 0.85 | KCNH2 (0.51) | KCNH2GCKSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27578456 | 0.83 | GCK (0.50) | KCNH2GCKOPRM1OPRK1SLC6A2 | |
| SCHEMBL27616367 | 0.83 | KCNH2 (0.52) | KCNH2GCKSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27635458 | 0.83 | KCNH2 (0.50) | KCNH2GCKOPRM1OPRK1SLC6A2 | |
| SCHEMBL27616350 | 0.83 | KCNH2 (0.48) | KCNH2GCKSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27635453 | 0.82 | KCNH2 (0.49) | KCNH2GCKSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |