Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642192 | 1.00 | GCK (0.50) | GCKKCNH2NOTUMOPRM1NPC1 | |
| SCHEMBL27578456 | 0.93 | GCK (0.50) | GCKKCNH2OPRM1PIK3CDPIK3CA | |
| SCHEMBL27557961 | 0.91 | KCNH2 (0.45) | GCKKCNH2NOTUMOPRM1NPC1 | |
| SCHEMBL2642234 | 0.90 | GCK (0.47) | GCKKCNH2NPC1LMNARAB9A | |
| SCHEMBL27558117 | 0.90 | KCNH2 (0.47) | GCKKCNH2NOTUMOPRM1NPC1 | |
| SCHEMBL2642140 | 0.90 | GCK (0.48) | GCKKCNH2NPC1MAPTRAB9A | |
| SCHEMBL27616313 | 0.84 | KCNH2 (0.51) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2657030 | 0.84 | GCK (0.67) | GCKKCNH2NPC1MAPTRAB9A | |
| SCHEMBL27557991 | 0.84 | KCNH2 (0.45) | GCKKCNH2OPRM1PIK3CDPIK3CA | |
| SCHEMBL27635452 | 0.83 | KCNH2 (0.51) | GCKKCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |