Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065211 | 0.80 | MAPT (0.56) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL210310 | 0.79 | NPC1 (0.61) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL10194257 | 0.79 | KDM4E (0.62) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL6508869 | 0.79 | MEN1 (0.82) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL11468806 | 0.79 | AURKA (0.59) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL31325204 | 0.79 | NPC1 (0.47) | KMT2AKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL5593087 | 0.77 | MEN1 (0.55) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL27268039 | 0.76 | KMT2A (0.56) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL444442 | 0.76 | KMT2A (0.56) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL2994671 | 0.76 | HSP90AA1 (0.66) | MEN1KMT2AKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1359376-A | Carboxylic acid derivatives compriosing aryl-substituted nitrogen heterocycles, their production and their use as endothel in receptor antagonists | BASF AG (DE) | 2002-07-17 | — | — | CN | disclosed |