Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279159 | 1.00 | PDE4B (0.43) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL278899 | 0.87 | PDE4B (0.49) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL279091 | 0.85 | PDE4B (0.39) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL275181 | 0.85 | PDE4B (0.39) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL275205 | 0.84 | PDE4B (0.52) | PDE4BPTPN2PTPN1PTPN6PDE4A | |
| SCHEMBL275719 | 0.78 | CHEK2 (0.44) | GPR119KDM4E | |
| SCHEMBL3086256 | 0.76 | PDE4B (0.44) | PDE4BUSP30GPR119STSMAPT | |
| SCHEMBL3090136 | 0.76 | PDE4B (0.44) | PDE4BUSP30GPR119STSMAPT | |
| SCHEMBL15321868 | 0.76 | NR1H2 (0.44) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3082480 | 0.76 | PDE4B (0.44) | PDE4BUSP30GPR119STSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | PDE4B 3594/4885PIK3CD 3156/4885PIK3CA 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.