Sugi Predict

Sugi Predict / Targets / SDHA

SDHA

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial · P31040 · SDHA on Sugi Atlas →

19,424 patent compounds predicted against SDHA, 14,432 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Linezolid Linezolid (SCHEMBL5027) 1.00 2/20
Linezolid Linezolid (SCHEMBL374752) 1.00 2/20
Linezolid Linezolid (SCHEMBL1561095) 1.00 2/20
SCHEMBL1498511 SCHEMBL1498511 0.80 2/20
Eperezolid Eperezolid (SCHEMBL186562) 0.76 2/20
Eperezolid Eperezolid (SCHEMBL1176950) 0.76 2/20
Acetic Acid Acetic Acid (SCHEMBL1338391) 0.74 2/20
Acetic Acid Acetic Acid (SCHEMBL1338393) 0.74 2/20
SCHEMBL1668749 SCHEMBL1668749 0.71 2/20
SCHEMBL701373 SCHEMBL701373 0.71 2/20
SCHEMBL1033023 SCHEMBL1033023 0.70 2/20
SCHEMBL1033024 SCHEMBL1033024 0.70 2/20
SCHEMBL76846 SCHEMBL76846 0.69 2/20
SCHEMBL1336215 SCHEMBL1336215 0.69 2/20
SCHEMBL1176771 SCHEMBL1176771 0.69 2/20
Linezolid Linezolid (SCHEMBL442039) 0.69 2/20
SCHEMBL1498671 SCHEMBL1498671 0.67 2/20
SCHEMBL1556211 SCHEMBL1556211 0.67 2/20
SCHEMBL1393698 SCHEMBL1393698 0.65 2/20
SCHEMBL1668751 SCHEMBL1668751 0.65 2/20

Clinical trials — most relevant to SDHA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Coenzyme Q10 in Older Athletes Treated With Statin Medications PHASE4COMPLETED
Phenoxybenzamine Versus Doxazosin in PCC Patients PHASE4COMPLETED
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer PHASE2ACTIVE_NOT_RECRUITING
Unacylated Ghrelin to Improve Functioning in PAD PHASE2COMPLETED
The Efficacy and Safety of Temozolomide in SDH-deficient GIST PHASE2RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
A Study of HQP1351 in Patients With GIST or Other Solid Tumors PHASE1RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study nanNOT_YET_RECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers nanNOT_YET_RECRUITING
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis nanCOMPLETED
Muscle OXPHOS and Nutrient Homeostasis nanCOMPLETED
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome. nanUNKNOWN
DNA QUANTIFICATION TECHNIQUE AS A INTERPRETATION TOOL IN MITOCHONDRIAL DISEASES nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SDHA binder may also engage these)

ProteinNameSimilarity
Q0QF01 — 1.000 Q0QF01 →
P31039 — 1.000 P31039 →
Q6PA58 — 1.000 Q6PA58 →
Q8HXW3 — 1.000 Q8HXW3 →
Q7ZVF3 — 1.000 Q7ZVF3 →
Q5R616 — 1.000 Q5R616 →
Q920L2 — 1.000 Q920L2 →
Q801S2 — 0.999 Q801S2 →
Q9YHT1 — 0.999 Q9YHT1 →
Q28ED0 — 0.999 Q28ED0 →
Q8WSR3 — 0.998 Q8WSR3 →
Q8K2B3 — 0.998 Q8K2B3 →
Q00711 — 0.998 Q00711 →
O82663 — 0.997 O82663 →
Q9UTJ7 — 0.997 Q9UTJ7 →
P47052 — 0.996 P47052 →
Q94523 — 0.996 Q94523 →
Q9ZPX5 — 0.995 Q9ZPX5 →
Q09508 — 0.995 Q09508 →
Q6ZDY8 — 0.995 Q6ZDY8 →
Q33862 — 0.991 Q33862 →
Q9U3X4 — 0.991 Q9U3X4 →
Q1RHB9 — 0.990 Q1RHB9 →
P0AC42 — 0.988 P0AC42 →
Q0QF17 — 0.986 Q0QF17 →
P0AC43 — 0.986 P0AC43 →
Q92J97 — 0.985 Q92J97 →
P31038 — 0.985 P31038 →
G4V4G6 — 0.984 G4V4G6 →
Q59661 — 0.983 Q59661 →