Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.64 |
| ▸ | HTR2C | P28335 | 15/20 | 0.64 |
| ▸ | HTR2B | P41595 | 7/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.64 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561126 | 0.82 | HTR2A (0.80) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL6088764 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL31079586 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4779282 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL475894 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL27595534 | 0.76 | METAP2 (0.39) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL27649403 | 0.76 | HTR2C (0.57) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL10252671 | 0.74 | HTR2A (0.71) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL8007544 | 0.73 | HTR2C (0.69) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL8009907 | 0.73 | HTR2C (0.69) | HTR2AHTR2CHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1231214-C | 5HT2 agonists for controlling IOP and treating glaucoma | ALCON LTD (CH) | 2005-12-14 | — | — | CN | claimed |
| CN-1450897-A | 5HT for controlling IOP and treating glaucoma2Stimulants | ALCON UNIVERSAL LTD (CH) | 2003-10-22 | — | — | CN | claimed |
| CN-1231214-C | 5HT2 agonists for controlling IOP and treating glaucoma | ALCON LTD (CH) | 2005-12-14 | — | — | CN | disclosed |
| CN-1450995-A | 5-hydroxy indazole derivatives for treating glaucoma | ALCON AG (CH) | 2003-10-22 | — | — | CN | disclosed |
| CN-1450897-A | 5HT for controlling IOP and treating glaucoma2Stimulants | ALCON UNIVERSAL LTD (CH) | 2003-10-22 | — | — | CN | disclosed |