Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582058 | 0.84 | MAPT (0.41) | MAPTALDH1A1PKMGAAPOLB | |
| SCHEMBL28749800 | 0.84 | MAPK1 (0.47) | MAPTALDH1A1GAANEK1LMNA | |
| SCHEMBL28747307 | 0.82 | ALDH1A1 (0.54) | ALDH1A1PKMPOLBILKNEK1 | |
| SCHEMBL27581877 | 0.81 | CA1 (0.41) | MAPTALDH1A1PKMMEN1KMT2A | |
| SCHEMBL27564363 | 0.78 | ALDH1A1 (0.37) | MAPTALDH1A1PKMGAAPOLB | |
| SCHEMBL13698175 | 0.78 | ALDH1A1 (0.49) | MAPTALDH1A1PKMGAAPOLB | |
| SCHEMBL13698113 | 0.77 | ALDH1A1 (0.48) | MAPTALDH1A1PKMGAAPOLB | |
| SCHEMBL27561520 | 0.74 | PDPK1 (0.41) | ALDH1A1IKBKBCHUKBRD4 | |
| SCHEMBL27582054 | 0.72 | DDB1 (0.33) | POLBTP53BRD4 | |
| SCHEMBL27561502 | 0.72 | KDM4E (0.56) | MAPTALDH1A1GAALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |