Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525088 | 0.89 | NCF1 (0.54) | NCF1KMT2AMEN1USP2HSD17B10 | |
| SCHEMBL27574131 | 0.84 | NCF1 (0.52) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL5404498 | 0.83 | NCF1 (0.55) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL5406740 | 0.81 | NCF1 (0.53) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL5401181 | 0.81 | NCF1 (0.74) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL5397410 | 0.80 | NCF1 (0.72) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL27550363 | 0.79 | NCF1 (0.59) | NCF1KMT2AMEN1NPY5RADRB2 | |
| SCHEMBL5420552 | 0.79 | NCF1 (0.50) | NCF1KMT2AMEN1ADRB2ADRB1 | |
| SCHEMBL5412918 | 0.79 | MEN1 (0.57) | NCF1KMT2AMEN1LMNAHSD17B10 | |
| SCHEMBL7137892 | 0.78 | NCF1 (0.55) | NCF1KMT2AMEN1NPY5RADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1274676-C | Quinoline and quinazoline derivatives | HOFFMANN LA ROCHE (CH) | 2006-09-13 | — | — | CN | disclosed |
| CN-1444563-A | Quinoline and quinazoline derivatives | HOFFMANN LA ROCHE (CH) | 2003-09-24 | — | — | CN | disclosed |