Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27564862 | 0.86 | KDM4E (0.51) | ALDH1A1KDM4ECHRNB2CHRNA4POLB | |
| SCHEMBL785972 | 0.85 | JAK2 (0.54) | ALDH1A1KDM4EKMT2ACHRM2JAK2 | |
| SCHEMBL27547624 | 0.83 | KDM4E (0.51) | ALDH1A1KDM4ECHRNB2CHRNA4LMNA | |
| SCHEMBL6583746 | 0.82 | KDM4E (0.78) | ALDH1A1KDM4ECHRNB2CHRNA4LMNA | |
| SCHEMBL27544648 | 0.82 | KDM4E (0.47) | ALDH1A1KDM4ECHRNB2CHRNA4POLB | |
| SCHEMBL3984660 | 0.79 | KMT2A (0.46) | ALDH1A1KDM4EKMT2AJAK2JAK1 | |
| SCHEMBL3130725 | 0.78 | KDM4E (0.72) | ALDH1A1KDM4ECHRNB2CHRNA4OPRK1 | |
| SCHEMBL18424508 | 0.78 | KMT2A (0.56) | KMT2ACHRM2JAK2JAK1MCHR1 | |
| SCHEMBL17297788 | 0.77 | ALDH1A1 (0.70) | ALDH1A1KDM4ECHRNB2CHRNA4LMNA | |
| SCHEMBL13744576 | 0.77 | ALDH1A1 (0.70) | ALDH1A1KDM4ECHRNB2CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | claimed |
| CN-1326519-C | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2007-07-18 | — | — | CN | disclosed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | disclosed |