Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28747106 | 0.93 | GCK (0.43) | GCKKCNH2HTTNPSR1SMN1; SMN2 | |
| SCHEMBL2642140 | 0.91 | GCK (0.48) | GCKKCNH2HTTNPSR1TDP1 | |
| SCHEMBL27557991 | 0.91 | KCNH2 (0.45) | GCKKCNH2HTTNPSR1 | |
| SCHEMBL27557961 | 0.91 | KCNH2 (0.45) | GCKKCNH2HTTNPSR1SMN1; SMN2 | |
| SCHEMBL2642234 | 0.84 | GCK (0.47) | GCKKCNH2HTTSMN1; SMN2RAB9A | |
| SCHEMBL2642093 | 0.81 | KCNH2 (0.63) | GCKKCNH2L3MBTL1MAPK1TSHR | |
| SCHEMBL2642090 | 0.81 | KCNH2 (0.63) | GCKKCNH2L3MBTL1MAPK1TSHR | |
| SCHEMBL27578456 | 0.81 | GCK (0.50) | GCKKCNH2HTTNPSR1 | |
| SCHEMBL2653752 | 0.81 | GCK (0.50) | GCKKCNH2HTTNPSR1SMN1; SMN2 | |
| SCHEMBL2642192 | 0.81 | GCK (0.50) | GCKKCNH2HTTNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | claimed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | claimed |
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |