Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897142 | 0.89 | POLB (0.72) | POLBALDH1A1GSK3BCYP19A1NOS1 | |
| SCHEMBL4875447 | 0.84 | POLB (0.82) | POLBALDH1A1MAPTTDP1GSK3B | |
| SCHEMBL4039612 | 0.82 | POLB (0.64) | POLBKCNJ1KDM4EALDH1A1MAPT | |
| SCHEMBL298658 | 0.82 | GSK3B (0.73) | POLBALDH1A1MAPTTDP1GSK3B | |
| SCHEMBL287513 | 0.79 | KCNJ1 (0.73) | POLBKCNJ1KCNH2 | |
| SCHEMBL6035088 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1MAPTGSK3BLMNA | |
| SCHEMBL2548153 | 0.78 | ALDH1A1 (0.57) | KCNH2KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL2616165 | 0.78 | MEN1 (0.69) | KDM4EALDH1A1ADRB1GSK3BLMNA | |
| SCHEMBL20421677 | 0.78 | MEN1 (0.47) | POLBKDM4EALDH1A1MAPTCYP19A1 | |
| SCHEMBL4877367 | 0.78 | KMT2A (0.53) | POLBKDM4EALDH1A1MAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1381448-A | Aralkylformylalkyl piperazine derivative and its application as brain nerve protector | SHANGHAI ACADEMY OF MEDICAL IN (CN) | 2002-11-27 | — | — | CN | claimed |