Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27654525 | 0.78 | KMT2A (0.37) | KDM4ESMN1; SMN2HDAC1HDAC6TYR | |
| SCHEMBL27836778 | 0.78 | HDAC1 (0.32) | HDAC1HDAC6 | |
| SCHEMBL83975 | 0.77 | NOS3 (0.50) | NOS3NOS2KDM4EHSD17B10GABRP | |
| SCHEMBL31222667 | 0.77 | NOS3 (0.50) | NOS3NOS2KDM4EHSD17B10GABRP | |
| SCHEMBL25327860 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2TYRALDH1A1 | |
| SCHEMBL27513382 | 0.77 | FDFT1 (0.34) | TYR | |
| SCHEMBL17203259 | 0.77 | NOS3 (0.38) | NOS3NOS2KDM4EHSD17B10GABRP | |
| SCHEMBL14647750 | 0.75 | NOS3 (0.48) | NOS3NOS2KDM4EHSD17B10GABRP | |
| SCHEMBL4328494 | 0.75 | NOS3 (0.48) | NOS3NOS2KDM4EHSD17B10GABRP | |
| SCHEMBL31477253 | 0.74 | KMT2A (0.44) | KDM4ENNMTMKNK1MKNK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316836-A | Substituted dihydroisoindolones as allosteric modulators of glucokinase | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-03 | — | — | CN | disclosed |
| CN-1455771-A | Cyclic amine phenyl Beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | disclosed |