Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.54 |
| ▸ | TUBB | P07437 | 2/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275835 | 1.00 | MDM2 (0.55) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL276805 | 0.93 | MDM2 (0.55) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL276804 | 0.93 | MDM2 (0.55) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL14673914 | 0.90 | NPC1 (0.70) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL14673913 | 0.90 | NPC1 (0.70) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| Tert-Butyl Formate SCHEMBL27817234 | 0.88 | MDM2 (0.51) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL13929330 | 0.87 | MDM2 (0.56) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12527251 | 0.86 | MDM2 (0.54) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL29443831 | 0.86 | MDM2 (0.54) | MDM2NPC1TUBB4ATUBBTUBA3C | |
| SCHEMBL13452982 | 0.86 | MDM2 (0.54) | MDM2NPC1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| EP-2229396-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077357-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | MDM2 918/4885NPC1 702/4885TUBB4A 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.