Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198825 | 0.84 | IDO1 (0.46) | LMNAMAOBKMT2A | |
| SCHEMBL27496458 | 0.82 | PTGS2 (0.50) | PTGS2PTGS1ALDH1A1LMNAMAOB | |
| SCHEMBL27475892 | 0.82 | ESR1 (0.38) | PTGS2PTGS1ALDH1A1LMNAMAPT | |
| SCHEMBL27459333 | 0.78 | MAPK1 (0.52) | FFAR1FFAR4ALDH1A1MAPTCA1 | |
| SCHEMBL27472788 | 0.77 | PTGS1 (0.72) | PTGS2PTGS1MAPK14 | |
| SCHEMBL28751578 | 0.76 | PTGS2 (0.56) | PTGS2PTGS1CA12CA1CA9 | |
| SCHEMBL27850508 | 0.76 | TAAR1 (0.50) | PTGS1SLC6A4FFAR1ALDH1A1LMNA | |
| SCHEMBL19953393 | 0.75 | MAPK14 (0.51) | PTGS2PTGS1MAOBMAPK14 | |
| SCHEMBL28181881 | 0.75 | CA12 (0.49) | CA12CA1CA9 | |
| SCHEMBL27458076 | 0.73 | PTGS2 (0.49) | PTGS2PTGS1FFAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1767835-A | Compositions comprising cyclooxygenase-2 selective inhibitors and glucosamine for the treatment and prevention of pain and inflammation | PHARMACIA CORP (US) | 2006-05-03 | — | — | CN | claimed |
| CN-1697654-A | Use of COx-2 inhibitors in combination with antiviral agents for the treatment of papilloma virus infections | UPJOHN CO (US) | 2005-11-16 | — | — | CN | claimed |
| CN-1575182-A | Compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate | PHARMACIA CORP (US) | 2005-02-02 | — | — | CN | claimed |
| CN-1561246-A | Compositions of cyclooxygenase-2 selective inhibitors and radiation for inhibition or prevention of cardiovascular disease | PHARMACIA CORP (US) | 2005-01-05 | — | — | CN | claimed |
| CN-1527709-A | Therapeutic combination for cardiovascular and inflammatory indications | — | 2004-09-08 | — | — | CN | claimed |
| CN-109906082-A | Use the combined therapy of immune DASH inhibitor and PGE2 antagonist | 塔夫茨大学信托人 | 2019-06-18 | — | — | CN | disclosed |
| CN-1771034-A | Combinations of peroxisome proliferators-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor | PHARMACIA CORP (US) | 2006-05-10 | — | — | CN | disclosed |
| CN-1767835-A | Compositions comprising cyclooxygenase-2 selective inhibitors and glucosamine for the treatment and prevention of pain and inflammation | PHARMACIA CORP (US) | 2006-05-03 | — | — | CN | disclosed |
| CN-1697654-A | Use of COx-2 inhibitors in combination with antiviral agents for the treatment of papilloma virus infections | UPJOHN CO (US) | 2005-11-16 | — | — | CN | disclosed |
| CN-1642544-A | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors | PHARMACIA CORP (US) | 2005-07-20 | — | — | CN | disclosed |
| CN-1638760-A | Treatment of pain, inflammation, and inflammation-related disorders with a combination of a cyclooxygenase-2 selective inhibitor and aspirin | PHARMACIA CORP (US) | 2005-07-13 | — | — | CN | disclosed |
| CN-1575182-A | Compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate | PHARMACIA CORP (US) | 2005-02-02 | — | — | CN | disclosed |
| CN-1561246-A | Compositions of cyclooxygenase-2 selective inhibitors and radiation for inhibition or prevention of cardiovascular disease | PHARMACIA CORP (US) | 2005-01-05 | — | — | CN | disclosed |