Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL28529603 | 0.92 | — | — | |
| Morpholine SCHEMBL922866 | 0.92 | — | — | |
| SCHEMBL6049109 | 0.92 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL986 | 0.92 | — | — | |
| Morpholine SCHEMBL18434 | 0.92 | — | — | |
| Morpholine SCHEMBL7996463 | 0.92 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL3233209 | 0.92 | MEN1 (0.92) | — | |
| SCHEMBL244992 | 0.92 | MEN1 (0.92) | — | |
| SCHEMBL22491036 | 0.92 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL18577399 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100439340-C | 3-cyanoquinolines, 3-cyano-1, 6-naphthyridines, and 3-cyano-1, 7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2008-12-03 | — | — | CN | disclosed |
| CN-1419545-A | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | disclosed |