Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27593151 | 1.00 | NR1H2 (0.38) | NR1H2THRATHRBTDP1ATM | |
| SCHEMBL28794950 | 1.00 | NR1H2 (0.38) | NR1H2THRATHRBTDP1ATM | |
| SCHEMBL27493732 | 0.93 | THRA (0.39) | NR1H2THRATHRBTDP1ATM | |
| SCHEMBL27979075 | 0.90 | NR1H2 (0.40) | NR1H2THRATHRB | |
| SCHEMBL27854238 | 0.88 | THRA (0.34) | NR1H2THRATHRB | |
| SCHEMBL27611212 | 0.86 | THRA (0.35) | THRATHRBTDP1ATM | |
| SCHEMBL27594438 | 0.86 | THRA (0.35) | THRATHRBTDP1ATM | |
| SCHEMBL27740843 | 0.86 | THRA (0.35) | THRATHRBTDP1ATM | |
| SCHEMBL27613018 | 0.86 | THRA (0.35) | THRATHRBTDP1ATM | |
| SCHEMBL27729891 | 0.86 | PLG (0.41) | THRATHRBTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102361863-B | Novel bicyclic antibiotics | BASILEA PHARMACEUTICA AG | 2014-12-03 | — | — | CN | disclosed |
| CN-102712640-A | Tricyclic heterocyclic compounds, compositions and methods of use thereof | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | disclosed |
| CN-102361863-A | Novel bicyclic antibiotics | BASILEA PHARMACEUTICA AG | 2012-02-22 | — | — | CN | disclosed |
| CN-1582281-A | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO LTD (JP) | 2005-02-16 | — | — | CN | disclosed |