Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214248 | 0.86 | MAPT (0.53) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL210097 | 0.83 | CYP1A2 (0.53) | MAPTALDH1A1KMT2ALMNAL3MBTL1 | |
| SCHEMBL210098 | 0.83 | CYP1A2 (0.53) | MAPTALDH1A1KMT2ALMNAL3MBTL1 | |
| SCHEMBL209426 | 0.77 | HDAC1 (0.68) | MAPTALDH1A1KMT2ALMNAHTT | |
| SCHEMBL7235855 | 0.75 | NPC1 (0.64) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL9042870 | 0.70 | MAPT (0.56) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8991608 | 0.69 | MAPT (0.55) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL14858956 | 0.65 | KEAP1 (0.59) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL2733568 | 0.63 | MAPT (0.61) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL12721852 | 0.62 | NPC1 (0.61) | MAPTMEN1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |