Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | MARK3 | P27448 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713441 | 0.87 | AURKA (0.51) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL27373098 | 0.79 | STK17A (0.55) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL4713221 | 0.79 | CDK1 (0.49) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL27371396 | 0.78 | MAPK8 (0.58) | AURKAIGF1RGSK3BJAK3SYK | |
| SCHEMBL4711379 | 0.77 | SIRT5 (0.48) | CDK2AURKAJAK3PTK2CSF1R | |
| SCHEMBL4715103 | 0.74 | EGFR (0.47) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL4712780 | 0.74 | CDK1 (0.53) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL4712777 | 0.74 | CDK1 (0.53) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL4715101 | 0.74 | EGFR (0.47) | CDK1CDK2AURKAIGF1RJAK2 | |
| SCHEMBL301484 | 0.74 | EGFR (0.57) | CDK1CDK2AURKAIGF1RJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1433417-A | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | WARNER LAMBERT CO (US) | 2003-07-30 | — | — | CN | disclosed |