Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 12/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398023 | 0.86 | KMT2A (0.47) | KMT2AFBP1F2PKMALDH1A1 | |
| SCHEMBL8394667 | 0.80 | KMT2A (0.47) | KMT2AFBP1ABCC9ABCC8KCNJ11 | |
| SCHEMBL9279135 | 0.74 | KMT2A (0.49) | KMT2AHCRTR2FBP1ALDH1A1 | |
| SCHEMBL3279948 | 0.74 | KMT2A (0.51) | KMT2AHCRTR2FBP1F2PKM | |
| SCHEMBL31435685 | 0.73 | KMT2A (0.53) | KMT2AFBP1F2ALDH1A1 | |
| SCHEMBL2612654 | 0.73 | KMT2A (0.58) | KMT2AHCRTR2FBP1PKMCNR1 | |
| SCHEMBL6113188 | 0.73 | KMT2A (0.53) | KMT2AFBP1F2ALDH1A1 | |
| SCHEMBL11521611 | 0.71 | KMT2A (0.49) | KMT2AFBP1F2PKMALDH1A1 | |
| SCHEMBL3280893 | 0.71 | KMT2A (0.52) | KMT2AFBP1F2ALDH1A1 | |
| SCHEMBL4662276 | 0.71 | KMT2A (0.49) | KMT2AHCRTR2FBP1F2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1642929-B | Kappa-opioid receptor agonists containing 2-phenylbenzothiazoline derivatives | SANTEN PHARMACEUTICAL CO LTD | 2010-05-12 | — | — | CN | disclosed |
| CN-100522954-C | Kappa-opioid receptor agonist composed of 2-phenylbenzothiazoline derivative | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |
| CN-1911918-A | Kappa-opioid receptor agonist composed of 2-phenylbenzothiazoline derivative | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-02-14 | — | — | CN | disclosed |
| CN-1642929-A | Kappa-opioid receptor agonists containing 2-phenylbenzothiazoline derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-07-20 | — | — | CN | disclosed |