Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 6/20 | 0.35 |
| ▸ | CYBB | P04839 | 2/20 | 0.35 |
| ▸ | TYMS | P04818 | 2/20 | 0.33 |
| ▸ | ATP4A | P20648 | 1/20 | 0.33 |
| ▸ | ATP4B | P51164 | 1/20 | 0.33 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735452 | 0.81 | TLR8 (0.46) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL14222963 | 0.79 | KDM4E (0.49) | MEN1ALDH1A1KMT2AQTRT1 | |
| SCHEMBL24834182 | 0.76 | DCPS (0.47) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL31723877 | 0.76 | DCPS (0.47) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL11176787 | 0.74 | MEN1 (0.40) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| Hydrochloric Acid SCHEMBL214354 | 0.72 | DDB1 (0.43) | MEN1ALDH1A1KMT2A | |
| SCHEMBL13058006 | 0.72 | MEN1 (0.44) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL30095152 | 0.72 | KMT2A (0.39) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL6015868 | 0.70 | DCPS (0.46) | — | |
| SCHEMBL14365376 | 0.69 | MEN1 (0.44) | MASP2MEN1ALDH1A1NUDT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |