Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 2/20 | 0.42 |
| ▸ | CPA2 | P48052 | 2/20 | 0.42 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208821 | 0.90 | CTSL (0.47) | CPA1CPA2CPA4MMP3CTSL | |
| SCHEMBL2760023 | 0.89 | CPA1 (0.48) | CPA1CPA2CPA4MMP3CTSL | |
| SCHEMBL2632751 | 0.89 | CPA1 (0.44) | CPA1CPA2CPA4PSMB5MMP3 | |
| SCHEMBL8270598 | 0.89 | CPA1 (0.47) | CPA1CPA2CPA4PSMB5MMP3 | |
| SCHEMBL2632750 | 0.88 | CPA1 (0.41) | CPA1CPA2CPA4PSMB5MMP3 | |
| SCHEMBL2632715 | 0.85 | CPA1 (0.49) | CPA1CPA2CPA4PSMB5MMP3 | |
| SCHEMBL2735653 | 0.82 | PSMB5 (0.52) | PSMB5CTSB | |
| SCHEMBL2632731 | 0.81 | CPA1 (0.50) | CPA1CPA2CPA4PSMB5MMP3 | |
| SCHEMBL14208668 | 0.79 | CTSL (0.49) | CPA1CPA2CPA4MMP3CTSL | |
| SCHEMBL2632733 | 0.79 | CPA1 (0.47) | CPA1CPA2CPA4PSMB5MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088741-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |