Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548794 | 0.86 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600700 | 0.85 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600701 | 0.82 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545232 | 0.81 | PDE4B (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27619126 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600688 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600769 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5196682 | 0.80 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30930191 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16774566 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | claimed |
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | disclosed |