Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.48 |
| ▸ | BPTF | Q12830 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 5/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27501218 | 0.94 | BPTF (0.65) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Fumaric Acid SCHEMBL27470110 | 0.92 | BPTF (0.61) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| SCHEMBL181761 | 0.86 | BPTF (1.00) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL9309714 | 0.85 | BPTF (0.96) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL4818062 | 0.85 | BPTF (0.96) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Fumaric Acid SCHEMBL27601350 | 0.83 | KDM4E (0.56) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| SCHEMBL5238778 | 0.80 | BPTF (0.87) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Fumaric Acid SCHEMBL27619902 | 0.80 | KDM4E (0.60) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL9219094 | 0.79 | BPTF (0.84) | BPTFKDM4ECYP3A4HSD17B10LMNA | |
| SCHEMBL6354020 | 0.79 | BPTF (0.84) | BPTFKDM4ECYP3A4HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100398103-C | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2008-07-02 | — | — | CN | disclosed |
| CN-1635877-A | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2005-07-06 | — | — | CN | disclosed |