Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 10/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27584170 | 0.86 | CYP3A4 (0.49) | MAPTELANEARCYP3A4CYP1A2 | |
| SCHEMBL27601669 | 0.83 | MAPT (0.39) | MAPTELANECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL27584102 | 0.83 | LMNA (0.39) | MAPTELANECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL27601683 | 0.82 | ELANE (0.33) | MAPTELANECYP3A4ALDH1A1LMNA | |
| SCHEMBL27584062 | 0.81 | MAPT (0.36) | MAPTELANECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL27601709 | 0.80 | CYP3A4 (0.36) | MAPTELANECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL28785936 | 0.80 | HTR1D (0.33) | MAPTELANECYP3A4ALDH1A1LMNA | |
| SCHEMBL27751458 | 0.79 | NR4A2 (0.52) | ELANEALDH1A1NR4A2KDM4E | |
| SCHEMBL27601684 | 0.75 | HTR1D (0.37) | MAPTELANECYP3A4CYP1A2CYP2C19 | |
| SCHEMBL27584067 | 0.74 | HTR1D (0.34) | MAPTELANECYP3A4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101214248-A | Triazolo[4,5-d] pyrimidine derivatives and their application as purinergic receptor antagonists | VERNALIS RES LTD (GB) | 2008-07-09 | — | — | CN | disclosed |
| CN-1496262-A | Triazolo [4, 5-d ] pyrimidine derivatives and their use as purinergic receptor antagonists | О | 2004-05-12 | — | — | CN | disclosed |