Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1234876 | 0.77 | SCN9A (0.36) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL6207856 | 0.73 | KDM4E (0.42) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL27604126 | 0.71 | PRKAB2 (0.48) | KDM4EALDH1A1KLK7PRKAB2PRKAG1 | |
| SCHEMBL4496683 | 0.71 | ACP1 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL1234014 | 0.70 | GSK3B (0.52) | KDM4E | |
| SCHEMBL4488611 | 0.70 | GSK3B (0.48) | FLT4KDRFLT3 | |
| SCHEMBL3519003 | 0.65 | CNR2 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL14158232 | 0.64 | NPC1 (0.43) | KDM4EALDH1A1EGFRIGF1RSRC | |
| SCHEMBL19950721 | 0.63 | ALK (0.44) | SRCKDRFLT3 | |
| SCHEMBL6486769 | 0.63 | GSK3B (0.60) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1982316-A | Novel aminoindazole derivatives as medicaments and pharmaceutical compositions including them | AVENTIS PHARMA SA (FR) | 2007-06-20 | — | — | CN | disclosed |
| CN-1678589-A | Novel aminoindazole derivatives as medicaments and pharmaceutical compositions containing them | AVENTIS PHARMA SA (FR) | 2005-10-05 | — | — | CN | disclosed |