Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746257 | 0.78 | CRHR1 (0.38) | CRHR1CYP1A2CYP2C19PHGDHHTR1A | |
| SCHEMBL27606346 | 0.78 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5493011 | 0.77 | CRHR1 (0.47) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL5487814 | 0.75 | CRHR1 (0.53) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL2190889 | 0.74 | CRHR1 (0.54) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL27624988 | 0.74 | CRHR1 (0.52) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL6746234 | 0.73 | CRHR1 (0.57) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL5497559 | 0.73 | CRHR1 (0.40) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL5493014 | 0.72 | CRHR1 (0.51) | CRHR1TRPV1CYP1A2CYP2C19PHGDH | |
| SCHEMBL5487816 | 0.71 | CRHR1 (0.53) | CRHR1TRPV1CYP1A2CYP2C19PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1649848-A | Fused pyrimidines derivatives as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LTD (GB) | 2005-08-03 | — | — | CN | claimed |
| CN-1649848-A | Fused pyrimidines derivatives as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LTD (GB) | 2005-08-03 | — | — | CN | disclosed |