Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | FOS | P01100 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16134092 | 0.83 | LMNA (0.40) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL29541506 | 0.79 | LMNA (0.39) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL1521534 | 0.79 | LMNA (0.39) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL30346051 | 0.79 | LMNA (0.39) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL3965244 | 0.79 | LMNA (0.39) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL1521589 | 0.79 | HTT (0.51) | LMNAKDM4EHTTALDH1A1SYK | |
| Hydrochloric Acid SCHEMBL3582648 | 0.78 | LMNA (0.38) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL6207973 | 0.76 | HTT (0.41) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL6208769 | 0.76 | LMNA (0.37) | LMNAKDM4EHTTALDH1A1SYK | |
| SCHEMBL3820985 | 0.76 | HTT (0.49) | LMNAKDM4EHTTALDH1A1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100432073-C | 6-alkoxy-pyrido-pyrimidines as p-38 MAP kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-1675207-A | 6-alkoxy-pyrido-pyrimidines as p-38 MAP kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |