Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30303084 | 1.00 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL29618260 | 0.83 | CYP2D6 (0.53) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL1655488 | 0.83 | CYP2D6 (0.53) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL29531493 | 0.82 | KDM4E (0.64) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL8796387 | 0.82 | KDM4E (0.64) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL27885978 | 0.80 | KDM4E (0.55) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL17652775 | 0.80 | CYP1A2 (0.57) | CYP2D6CYP1A2CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL17921471 | 0.79 | CYP1A2 (0.58) | CYP2D6CYP1A2CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL3280339 | 0.78 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP2C19KDM4ETSHR | |
| SCHEMBL14421398 | 0.78 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP2C19KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101348471-B | Process for the preparation of 4- (3'chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline | ASTRAZENECA AB | 2011-01-26 | — | — | CN | claimed |
| CN-101348471-A | Process for the preparation of 4- (3'chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | CN | claimed |
| CN-1681796-A | Process for preparing 4- (3 '-chloro-4' -fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | claimed |