Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29531493 | 1.00 | KDM4E (0.64) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL8642141 | 0.93 | DRD1 (0.58) | KDM4EMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL27885978 | 0.87 | KDM4E (0.55) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL3583983 | 0.86 | CYP2D6 (0.60) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL30303084 | 0.82 | CYP2D6 (0.63) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL27608201 | 0.82 | CYP2D6 (0.63) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL6431609 | 0.82 | HRH3 (0.52) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL6052299 | 0.82 | HRH3 (0.52) | KDM4ECYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL11162539 | 0.81 | MEN1 (0.64) | KDM4ECYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL11234384 | 0.79 | MEN1 (0.71) | KDM4EMEN1KMT2AHRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |