Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 2/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27609879 | 0.83 | MAPK1 (0.46) | USP28USP25KDM4EKDM5AKDM5C | |
| SCHEMBL27609866 | 0.82 | USP28 (0.45) | USP28USP25KDM4EKDM5AKDM5C | |
| SCHEMBL6316706 | 0.81 | GAA (0.46) | KDM4ESMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL28750979 | 0.80 | MEN1 (0.48) | USP28USP25KDM4EKDM5AKDM5C | |
| SCHEMBL27591452 | 0.74 | NPC1 (0.55) | USP28USP25MYCSMN1; SMN2NPC1 | |
| SCHEMBL6322686 | 0.73 | CA1 (0.53) | SMN1; SMN2NPC1RAB9AHDAC2MEN1 | |
| SCHEMBL6315993 | 0.73 | ECE1 (0.41) | RAB9AHDAC2GAAHDAC3HDAC4 | |
| SCHEMBL6318335 | 0.73 | NPC1 (0.50) | SMN1; SMN2NPC1RAB9AL3MBTL1FAAH | |
| SCHEMBL6317256 | 0.72 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL27591690 | 0.71 | KDM4E (0.42) | KDM4ERAB9AL3MBTL1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1549714-A | Aminoisoxazole derivatives active as kinase inhibitors | — | 2004-11-24 | — | — | CN | claimed |