Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | RAD52 | P43351 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612456 | 0.75 | NEK2 (0.46) | MAPTKMT2APOLBKDM4EHPGD | |
| SCHEMBL27612534 | 0.73 | MBOAT4 (0.43) | KMT2AFLT3JAK2HPGD | |
| SCHEMBL27631625 | 0.73 | NEK2 (0.46) | SYKKDM4EHPGD | |
| SCHEMBL656368 | 0.72 | EGFR (0.61) | EGFRSYKMAPK8MAPK9 | |
| SCHEMBL1222450 | 0.71 | AURKA (0.51) | MAPTTP53RAD52KMT2AMEN1 | |
| SCHEMBL27612634 | 0.71 | CA12 (0.47) | EGFRKDM4EHPGD | |
| SCHEMBL2849165 | 0.69 | GAA (0.51) | MAPTEGFRKDM4EHPGD | |
| SCHEMBL15541724 | 0.68 | KDM4E (0.54) | MAPTKMT2AMEN1POLBEGFR | |
| SCHEMBL27612697 | 0.68 | RHOA (0.58) | KMT2AMEN1JAK2SYK | |
| SCHEMBL12853005 | 0.67 | EGFR (0.55) | MAPTKMT2AMEN1POLBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |