Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAD52 | P43351 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | YWHAG | P61981 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612641 | 0.88 | NR1H2 (0.42) | NR1H2KDM4EHSD17B3MAPTRAD52 | |
| SCHEMBL27612650 | 0.78 | P2RX4 (0.44) | KDM4EHSD17B3MAPTMEN1KMT2A | |
| SCHEMBL25321379 | 0.75 | KDM4E (0.59) | NR1H2KDM4EHSD17B3MAPTHSD17B10 | |
| SCHEMBL30475924 | 0.75 | KDM4E (0.59) | NR1H2KDM4EHSD17B3MAPTHSD17B10 | |
| SCHEMBL6295386 | 0.70 | NR1H2 (0.60) | NR1H2KDM4EHSD17B3MAPTRAD52 | |
| SCHEMBL27612384 | 0.70 | LMNA (0.44) | MAPTKMT2AHSD17B10THRBNPC1 | |
| SCHEMBL2306434 | 0.69 | BRD4 (0.51) | NR1H2KDM4EHSD17B3MAPTKMT2A | |
| SCHEMBL29963540 | 0.69 | BRD4 (0.51) | NR1H2KDM4EHSD17B3MAPTKMT2A | |
| SCHEMBL30664595 | 0.67 | KDM4E (0.54) | KDM4EMAPTRAD52GFERMEN1 | |
| SCHEMBL6839630 | 0.67 | MAPT (0.56) | KDM4EMAPTRAD52GFERMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |