Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14421756 | 0.86 | NPY5R (0.45) | NPC1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL27614994 | 0.83 | SMN1; SMN2 (0.43) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL5570000 | 0.78 | NPC1 (0.48) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL27596188 | 0.76 | NPY5R (0.40) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL5569998 | 0.76 | NPC1 (0.48) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL27677959 | 0.76 | NPC1 (0.50) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL27614917 | 0.75 | F2 (0.37) | ALDH1A1KDM4EHSD17B10MAPK1 | |
| SCHEMBL5564500 | 0.73 | LCK (0.43) | NPC1RAB9AKMT2ACLK2GSK3A | |
| SCHEMBL14421688 | 0.73 | SCN1A (0.43) | NPC1ALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL27614922 | 0.71 | MAPK13 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |