Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819175 | 0.77 | SIRT3 (0.38) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL27738537 | 0.77 | LOXL2 (0.37) | — | |
| Bromide SCHEMBL6450377 | 0.76 | SIRT3 (0.37) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL27549906 | 0.75 | ESR1 (0.41) | CYP3A4CYP2D6CYP2C9CYP2C19GAA | |
| SCHEMBL27626766 | 0.75 | SIRT3 (0.39) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL25228387 | 0.74 | GAA (0.40) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL30488169 | 0.74 | GAA (0.40) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL27614983 | 0.73 | TDP1 (0.42) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| Hydrochloric Acid SCHEMBL3976304 | 0.72 | SIRT3 (0.37) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 | |
| Bromide SCHEMBL27607832 | 0.72 | TDP1 (0.41) | SIRT3TDP1CYP1A2CYP2E1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100381429-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-16 | — | — | CN | disclosed |
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1675188-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |