Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27614981 | 0.91 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27614995 | 0.89 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27614966 | 0.85 | GCGR (0.39) | MAPK14 | |
| SCHEMBL27614917 | 0.85 | F2 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596142 | 0.84 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27614961 | 0.84 | LCK (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564741 | 0.84 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14421687 | 0.83 | NPY5R (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14421713 | 0.82 | NPY5R (0.43) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596205 | 0.82 | MAPK14 (0.43) | MAPK14CCNB2CCNE2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |