Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596165 | 0.90 | TOP2A (0.40) | MAPK14L3MBTL1TOP2A | |
| SCHEMBL27596179 | 0.89 | MAPK13 (0.43) | MAPK14CCNB2CCNE2CDK1CCNB1 | |
| SCHEMBL27596213 | 0.89 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL27596180 | 0.89 | LIMK1 (0.40) | MAPK14LIMK1LCK | |
| SCHEMBL27596405 | 0.89 | MAPK14 (0.38) | MAPK14TOP2ALCK | |
| SCHEMBL27615061 | 0.88 | LIMK1 (0.41) | L3MBTL1TOP2ALIMK1 | |
| SCHEMBL27614968 | 0.83 | ALDH1A1 (0.41) | MAPK14L3MBTL1TOP2ALCK | |
| SCHEMBL27615012 | 0.82 | MAPK14 (0.42) | MAPK14CCNB2CCNE2CDK1CCNB1 | |
| SCHEMBL5563863 | 0.82 | MAPK14 (0.46) | MAPK14LIMK1LCK | |
| SCHEMBL27596193 | 0.82 | PKM (0.44) | MAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |