Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.57 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.48 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761399 | 0.88 | LPAR1 (0.54) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL6003 | 0.87 | LPAR1 (0.54) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL2761476 | 0.87 | LPAR1 (0.65) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL1345 | 0.87 | LPAR1 (0.53) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL2761269 | 0.85 | LPAR1 (0.63) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL12973654 | 0.85 | LPAR1 (0.63) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL18746102 | 0.84 | LPAR1 (0.49) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL12973580 | 0.83 | LPAR1 (0.60) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL15897508 | 0.83 | LPAR1 (0.60) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL2761499 | 0.83 | LPAR1 (0.49) | LPAR1LPAR3ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |